Indirubin-3'-monoxime Inhibitor

Indirubin-3'-oxime is a potent inhibitor of GSK3beta (IC50: 22nM) and also inhibits CDKs ((IC50s: 100/180/250nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).

1. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors J Biol Chem. 2001 Jan 5;276 (1):251-60.
2. Damiens E, et al. Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest. Oncogene. 2001 Jun 28;20 (29):3786-97.
3. Blazevic T, et al. Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration. Cardiovasc Res. 2014 Mar 1;101 (3):522-32.
4. Sharma S, et al. Neuroprotective role of Indirubin-3'-monoxime, a GSKbeta inhibitor in high fat diet induced cognitive impairment in mice. Biochem Biophys Res Commun. 2014 Oct 3;452 (4):12009-15.

Small volumes of Indirubin-3'-monoxime, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751644 is an inhibitor targeting Indirubin-3'-monoxime.