TR-14035 Inhibitor

Name: TR-14035 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751741
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751741

TR-14035 is a dual antagonist of alpha4beta7/alpha4beta1 integrins (IC50s: 7/87nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TR-14035, Inhibitor

Full Product Name

TR-14035

Product Gene Name

TR-14035, inhibitor

Product Synonym Names

TR14035; TR 14035; MDK-1191

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

474.33

Formula

C24H21Cl2NO5

CAS

232271-19-1

Smiles

COc1cccc(OC)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(O)=O)cc1

Receptor (IC50)

alpha4beta7 integrin: 7nM
alpha4beta1 integrin: 87nM

Solubility

DMSO: 40mg/Ml, 84.3mM
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for TR-14035, inhibitor

Home; Cytoskeletal Signaling; Integrin

Product References and Citations for TR-14035, inhibitor

1. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha (4)beta (7)/alpha (4)beta (1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10 (6):2051-66.
2. Tsuda-Tsukimoto M, et al. Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharm Res. 2006 Nov;23 (11):2646-56.
3. Egger LA, et al. Alpha (4)beta (7)/alpha (4)beta (1) dual integrin antagonists block alpha (4)beta (7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302 (1):153-62.

Other Notes

Small volumes of TR-14035, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TR-14035 purchase

MBS5751741 is an inhibitor targeting TR-14035.