Sobetirome Inhibitor

Name: Sobetirome Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751743
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751743

Sobetirome is a selective agonist of thyroid hormone receptor beta (TRbeta) and binds selectively to TRbeta-1 (EC50: 0.16uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sobetirome, Inhibitor

Full Product Name

Sobetirome

Product Synonym Names

QRX-431; IACS-010759

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

328.4

Formula

C20H24O4

CAS

211110-63-3

Smiles

CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O

Receptor (IC50)

TRbeta-1: 0.16uM (EC50)
TRalpha-1: 0.58uM (EC50)

Solubility

DMSO: 30mg/mL, 91.4mM
Ethanol: 30mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Sobetirome, inhibitor

Home; Endocrinology/Hormones; Thyroid hormone receptor (THR)

Product References and Citations for Sobetirome, inhibitor

1. Gierach I, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012 Aug 15;2:247-53.
2. Puliga E, et al. Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017 Nov;187 (11):2473-2485.
3. Johansson L, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102 (29):10297-302.
4. Columbano A, et al. The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology. 2006 Jul;147 (7):3211-8.

Other Notes

Small volumes of Sobetirome, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sobetirome purchase

MBS5751743 is an inhibitor targeting Sobetirome.