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666-15 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751747

MBS5751747 is an inhibitor targeting 666-15. 666-15 is a potent and selective CREB inhibitor (IC50: 81nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
666-15, Inhibitor
Full Product Name
666-15
Product Gene Name
666-15, inhibitor
Product Synonym Names
CREB inhibitor; CREB inhibitor
Form/Format
Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
620.52
Formula
C33H31Cl2N3O5
CAS
1433286-70-4
Smiles
Cl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
Receptor (IC50)
CREB: 81nM (in HEK 293T cells)
Solubility
DMSO: 20mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for 666-15, inhibitor

Home; Chromatin/Epigenetic; Epigenetic Reader Domain

Structure of 666-15, inhibitor

666-15 Inhibitor – Cat# MBS5751747

Product References and Citations for 666-15, inhibitor

1. Xie F, et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58 (12):5075-87.
2. Yang C, et al. Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway. Front Neurosci. 2019 Jan 7;12:1990.
3. Li BX, et al. Systemic Inhibition of CREB is Well-tolerated in vivo. Sci Rep. 2016 Oct 3;6:34513.

Other Notes

Small volumes of 666-15, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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