JG-98 Inhibitor

Name: JG-98 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751774
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751774

JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JG-98, Inhibitor

Full Product Name

JG-98

Product Gene Name

JG-98, inhibitor

Product Synonym Names

JG98; JG 98

Form/Format

Powder

Purity/Purification

99.35%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

534.53

Formula

C24H21Cl2N3OS3

CAS

1456551-16-8

Smiles

[Cl-].CCn1c(=O)\c(s\c1=C/c1scc[n+]1Cc1ccccc1)=C1/Sc2cc(Cl)ccc2N1C

Receptor (IC50)

HSP70

Solubility

DMSO: 5mg/mL (9.35mM), Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for JG-98, inhibitor

Home; Cytoskeletal Signaling; HSP

Product References and Citations for JG-98, inhibitor

1. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4 (11).
2. Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14 (3):642-8.
3. Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8 (1):3010.

Other Notes

Small volumes of JG-98, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JG-98 purchase

MBS5751774 is an inhibitor targeting JG-98.