NAcM-OPT Inhibitor

Name: NAcM-OPT Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751790
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751790

NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NAcM-OPT, Inhibitor

Full Product Name

NAcM-OPT

Product Gene Name

NAcM-OPT, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

434.4

Formula

C23H29Cl2N3O

CAS

2089293-61-6

Smiles

CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1

Receptor (IC50)

DCN1-UBE2M: 79nM (cell free)

Solubility

DMSO: 100mg/mL, 230.20mM
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for NAcM-OPT, inhibitor

Home; Others

Product References and Citations for NAcM-OPT, inhibitor

1. Scott DC, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol. 2017 Aug;13 (8):850-857.
2. Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61 (7):2694-2706.

Other Notes

Small volumes of NAcM-OPT, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NAcM-OPT purchase

MBS5751790 is an inhibitor targeting NAcM-OPT.