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PF-06651600 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751795

MBS5751795 is an inhibitor targeting PF-06651600. PF-06651600 is a potent JAK3-selective inhibitor (IC50: 33.1nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-06651600, Inhibitor
Full Product Name
PF-06651600
Product Gene Name
PF-06651600, inhibitor
Form/Format
Powder
Purity/Purification
98.81%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
285.34
Formula
C15H19N5O
CAS
1792180-81-4
Smiles
C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12
Receptor (IC50)
JAK3: 33.1nM (cell free
Solubility
DMSO: 130mg/mL, 455.60mM
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for PF-06651600, inhibitor

Home; Angiogenesis; JAK

Structure of PF-06651600, inhibitor

PF-06651600 Inhibitor – Cat# MBS5751795

Product References and Citations for PF-06651600, inhibitor

1. Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11 (12):3442-3451.
2. Thorarensen A, et al. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1- ((2S,5R)-5- ((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem. 2017 Mar 9;60 (5):1971-1993.

Other Notes

Small volumes of PF-06651600, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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