TP0463518 Inhibitor

Name: TP0463518 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751803
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751803

TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13nM and 18nM for human and rat PHD2, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TP0463518, Inhibitor

Full Product Name

TP0463518

Product Gene Name

TP0463518, inhibitor

Form/Format

Powder

Purity/Purification

99.43%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

431.83

Formula

C20H18ClN3O6

CAS

1558021-37-6

Smiles

OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O

Receptor (IC50)

PHD1 (human): 18nM (cell free)
PHD2 (human): 13nM (cell free)
PHD3 (human): 63nM (cell free)
PHD2 (rat): 18nM (cell free)

Solubility

DMSO: 110mg/mL (254.73mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for TP0463518, inhibitor

Home; Chromatin/Epigenetic; HIF/HIF Prolyl-Hydroxylase

Product References and Citations for TP0463518, inhibitor

1. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.

Other Notes

Small volumes of TP0463518, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TP0463518 purchase

MBS5751803 is an inhibitor targeting TP0463518.