A-381393 Inhibitor

Name: A-381393 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751808
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751808

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6nM for human dopamine D4.2/D4.4/D4.7 receptor). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

A-381393, Inhibitor

Full Product Name

A-381393

Product Gene Name

A-381393, inhibitor

Form/Format

Powder

Purity/Purification

99.92%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

320.43

Formula

C20H24N4

CAS

726174-00-1

Smiles

Cc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1

Receptor (IC50)

D4.4 receptor: 1.5nM (Ki, cell free)
D4.2 receptor: 1.9nM (Ki, cell free)
D4.7 receptor: 1.6nM (Ki, cell free)

Solubility

DMSO: 50mg/mL (156.04mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for A-381393, inhibitor

Home; GPCR/G Protein; Dopamine Receptor

Product References and Citations for A-381393, inhibitor

1. Nakane M, et al. 2-[4- (3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49 (1):112-21.
2. Bitner RS, et al. Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. Neuropharmacology. 2006 Apr;50 (5):521-31.

Other Notes

Small volumes of A-381393, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A-381393 purchase

MBS5751808 is an inhibitor targeting A-381393.