BMS599626 Inhibitor – BMS 599626

Name: BMS599626 Inhibitor; BMS 599626; MyBioSource
Brand: MyBioSource
SKU: MBS5751809
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751809

BMS-599626 (AC480) is a selective inhibitor of HER1 and HER2 (IC50s: 20nM and 30nM), ~8-fold less potent to HER4, >100-fold to Lck, VEGFR2, c-Kit, MET, etc. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BMS 599626 (BMS599626), Inhibitor

Full Product Name

BMS 599626 2HCl (873837-23-1 (HCl))

Product Gene Name

BMS599626, inhibitor

Product Synonym Names

AC480 dihydrochloride

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

603.47

Formula

C27H29Cl2FN8O3

Smiles

Cl.Cl.Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c12

Receptor (IC50)

HER1: 20nM (cell free)
HER2: 30nM (cell free)
HER3: 190nM (cell free)

Solubility

DMSO: 95mg/mL (167.55mM)
Water: 3mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for BMS599626, inhibitor

Home; Angiogenesis; HER

Product References and Citations for BMS599626, inhibitor

1. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12 (20 Pt 1):6186-93.
2. Gavai AV, et al. Discovery and preclinical evaluation of [4-[[1- (3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases. J Med Chem. 2009 Nov 12;52 (21):6527-30.
3. Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29 (4):554-61.

Other Notes

Small volumes of BMS599626, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMS599626 purchase

MBS5751809 is an inhibitor targeting BMS599626. Also known as BMS 599626 2HCl (873837-23-1 (HCl)).