Q203 Inhibitor

Name: Q203 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751811
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751811

Q203 is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Q203, Inhibitor

Full Product Name

Q203

Product Gene Name

Q203, inhibitor

Product Synonym Names

IAP6; Telacebec

Form/Format

Powder

Purity/Purification

99.47%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

557

Formula

C29H28ClF3N4O2

CAS

1334719-95-7

Smiles

CCc1nc2ccc(Cl)cn2c1C(=O)NCc1ccc(cc1)N1CCC(CC1)c1ccc(OC(F)(F)F)cc1

Receptor (IC50)

Mycobacterium tuberculosis H37Rv: 2.7nM (MIC50)

Solubility

DMSO: 18mg/mL (32.3mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Q203, inhibitor

Home; Microbiology & virology; Antibiotic

Product References and Citations for Q203, inhibitor

1. Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19 (9):1157-60.
2. Jang J, et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017 Jun 27;61 (7). pii: e02637-16.
3. Lu P, et al. The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd. Sci Rep. 2018 Feb 8;8 (1):2625.

Other Notes

Small volumes of Q203, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Q203 purchase

MBS5751811 is an inhibitor targeting Q203.