DDR1-IN-2 Inhibitor

Name: DDR1-IN-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751813
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751813

DDR1-IN-2 (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8nM in cell-free kinase assays). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DDR1-IN-2, Inhibitor

Full Product Name

DDR1-IN-2

Product Gene Name

DDR1-IN-2, inhibitor

Product Synonym Names

DDR1 inhibitor 7rh

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

546.59

Formula

C30H29F3N6O

CAS

1429617-90-2

Smiles

CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F

Receptor (IC50)

DDR1: 6.8nM (cell free)
DDR2: 101.4nM (cell free)

Solubility

DMSO: 12mg/mL (21.95mM), 18.3mM
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for DDR1-IN-2, inhibitor

Home; Others

Product References and Citations for DDR1-IN-2, inhibitor

1. Gao M, et al. Discovery and optimization of 3- (2- (Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem. 2013 Apr 25;56 (8):3281-95.
2. Aguilera KY, et al. Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017 Nov;16 (11):2473-2485.
3. Wang Z, et al. Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Med Chem Lett. 2017 Feb 9;8 (3):327-332.

Other Notes

Small volumes of DDR1-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDR1-IN-2 purchase

MBS5751813 is an inhibitor targeting DDR1-IN-2.