ML216 Inhibitor

Name: ML216 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751823
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751823

ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8uM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s >50uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ML216, Inhibitor

Full Product Name

ML216

Product Gene Name

ML216, inhibitor

Product Synonym Names

CID-49852229

Form/Format

Powder

Purity/Purification

96.83%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

383.32

Formula

C15H9F4N5OS

CAS

1430213-30-1

Smiles

Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F

Receptor (IC50)

BLM: 1.8uM

Solubility

DMSO: 5mg/mL (13mM), Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for ML216, inhibitor

Home; DNA Damage/DNA Repair; DNA/RNA Synthesis

Product References and Citations for ML216, inhibitor

1. Rosenthal AS, et al. Synthesis and SAR studies of 5- (pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett. 2013 Oct 15;23 (20):5660-6.
2. Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20 (1):55-62.

Other Notes

Small volumes of ML216, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ML216 purchase

MBS5751823 is an inhibitor targeting ML216.