ARV-825 Inhibitor

Name: ARV-825 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751842
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751842

ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARV-825, Inhibitor

Full Product Name

ARV-825

Product Gene Name

ARV-825, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

923.43

Formula

C46H47ClN8O9S

CAS

1818885-28-7

Smiles

O=C1NC(=O)CCC1N8C(=O)c7cccc(NCCOCCOCCOCCOc2ccc(cc2)NC(=O)C[C@@H]5N=C(c3ccc(Cl)cc3)c6c(C)c(C)sc6n4c(C)nnc45)c7C8=O

Receptor (IC50)

BRD4

Solubility

DMSO: 50mg/mL (54.15mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for ARV-825, inhibitor

Home; Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for ARV-825, inhibitor

1. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22 (6):755-63.

Other Notes

Small volumes of ARV-825, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARV-825 purchase

MBS5751842 is an inhibitor targeting ARV-825.