DBET57 Inhibitor

Name: DBET57 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751843
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751843

dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500nM,and inactive on BRD4BD2 More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dbet57, Inhibitor

Full Product Name

Dbet57

Product Gene Name

Dbet57, inhibitor

Form/Format

Powder

Purity/Purification

99.52%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

699.18

Formula

C34H31ClN8O5S

CAS

1883863-52-2

Smiles

Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCNc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1

Receptor (IC50)

BRD4

Solubility

DMSO: 250mg/mL (357.56mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Dbet57, inhibitor

Home; Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for Dbet57, inhibitor

1. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14 (7):706-714.

Other Notes

Small volumes of Dbet57, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dbet57 purchase

MBS5751843 is an inhibitor targeting Dbet57.