GNE-6640 Inhibitor

Name: GNE-6640 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751861
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751861

GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75uM, 0.43uM, 20.3uM and 0.23uM for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNE-6640, Inhibitor

Full Product Name

GNE-6640

Product Gene Name

GNE-6640, inhibitor

Product Synonym Names

GNE 6640; GNE6640

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

330.39

Formula

C20H18N4O

CAS

2009273-67-8

Smiles

CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1

Receptor (IC50)

full length USP7: 0.75uM
USP7 catalytic domain: 0.43uM
full length USP43: 20.3uM
Ub-MDM2: 0.23uM

Solubility

DMSO: 5mg/mL (15.13mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GNE-6640, inhibitor

Home; Ubiquitination; DUB; GNE-6640

Product References and Citations for GNE-6640, inhibitor

1. Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550 (7677):534-538.

Other Notes

Small volumes of GNE-6640, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-6640 purchase

MBS5751861 is an inhibitor targeting GNE-6640.