ASP-5878 Inhibitor

Name: ASP-5878 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751871
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751871

ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5nMol/L. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ASP-5878, Inhibitor

Full Product Name

ASP-5878

Product Gene Name

ASP-5878, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

407.38

Formula

C18H19F2N5O4

CAS

1453208-66-6

Smiles

COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F

Receptor (IC50)

FGFR1: 0.47nM
FGFR2: 0.6nM
FGFR3: 0.74nM
FGFR4: 3.5nM

Solubility

DMSO: 250mg/mL (613.69mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for ASP-5878, inhibitor

Home; Angiogenesis; FGFR

Product References and Citations for ASP-5878, inhibitor

1. Futami T, et al. ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma. Mol Cancer Ther. 2017 Jan;16 (1):68-75.

Other Notes

Small volumes of ASP-5878, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASP-5878 purchase

MBS5751871 is an inhibitor targeting ASP-5878.