TRi-1 Inhibitor

Name: TRi-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751879
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751879

TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12nM. TRi-1 has little mitochondrial toxicity for anticancer therapy More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRi-1, Inhibitor

Full Product Name

TRi-1

Product Gene Name

TRi-1, inhibitor

Form/Format

Powder

Purity/Purification

98.40%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

328.72

Formula

C12H9ClN2O5S

CAS

246020-68-8

Smiles

COc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O

Receptor (IC50)

TXNRD1: 12nM

Solubility

DMSO: 62.5mg/mL (190.13mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for TRi-1, inhibitor

Home; Others

Product References and Citations for TRi-1, inhibitor

1. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10 (428). pii: eaaf7444.

Other Notes

Small volumes of TRi-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRi-1 purchase

MBS5751879 is an inhibitor targeting TRi-1.