AK-7 Inhibitor

Name: AK-7 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751886
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751886

AK-1 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models.with an IC50 of 15.5uM More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AK-7, Inhibitor

Full Product Name

AK-7

Product Gene Name

AK-7, inhibitor

Form/Format

Powder

Purity/Purification

98.40%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

437.35

Formula

C19H21BrN2O3S

CAS

420831-40-9

Smiles

Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1

Receptor (IC50)

SIRT2: 15.5uM

Solubility

DMSO: 50mg/mL (114.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for AK-7, inhibitor

Home; Chromatin/Epigenetic; Sirtuin

Product References and Citations for AK-7, inhibitor

1. Taylor DM, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6 (6):540-6.
2. Machado D O R, Jana S, Kazantsev A G, et al. SIRT2 as a Therapeutic Target for Age-Related Disorders[J]. Frontiers in Pharmacology, 2012, 3.
3. Fridén-Saxin, Maria, Seifert T, Landergren, Marie Rydén, et al. Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors[J]. Journal of Medicinal Chemistry, 2012, 55 (16):7104-7113.
4. Szego EM, et al. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3beta/beta-catenin pathway. Neurobiol Aging. 2017 Aug;56:7-16.

Other Notes

Small volumes of AK-7, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AK-7 purchase

MBS5751886 is an inhibitor targeting AK-7.