Aurora Kinase III Inhibitor

Name: Aurora Kinase III Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751902
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751902

Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aurora Kinase III, Inhibitor

Full Product Name

Aurora Kinase Inhibitor III

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

413.4

Formula

C21H18F3N5O

CAS

879127-16-9

Smiles

FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1

Receptor (IC50)

Aurora A: 42nM

Solubility

DMSO: 50mg/mL (120.9mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Aurora Kinase III, inhibitor

Home; Cell Cycle/Checkpoint; Aurora Kinase

Product References and Citations for Aurora Kinase III, inhibitor

1. Zhang Q, Liu Y, Gao F, et al. Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library[J]. Journal of the American Chemical Society, 2006, 128 (7):2182-2183.
2. Tari L W, Hoffman I D, Bensen D C, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (3):688-691.

Other Notes

Small volumes of Aurora Kinase III, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Aurora Kinase III purchase

MBS5751902 is an inhibitor targeting Aurora Kinase III. Also known as Aurora Kinase Inhibitor III.