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LOC14 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751907

MBS5751907 is an inhibitor targeting LOC14. LOC14 to be the most potent PDI inhibitor reported to date (EC50 : 500nM) More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LOC14, Inhibitor
Full Product Name
LOC14
Product Gene Name
LOC14, inhibitor
Form/Format
Powder
Purity/Purification
98.22%
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Molecular Weight
317.4
Formula
C16H19N3O2S
CAS
877963-94-5
Smiles
O=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1
Receptor (IC50)
PDI: 500nM (EC50)
Solubility
DMSO: 25mg/mL (78.76mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for LOC14, inhibitor

Home; Others

Structure of LOC14, inhibitor

LOC14 Inhibitor – Cat# MBS5751907

Product References and Citations for LOC14, inhibitor

1. Kaplan A, et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17):E2245-52.
2. Zhou X, Li G, Kaplan A, et al. Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease[J]. Human Molecular Genetics, 2018.

Other Notes

Small volumes of LOC14, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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