Coenzyme Q9 Inhibitor

Coenzyme Q9 (CoQ9) is a normal constituent of human plasma. CoQ9 in human plasma may originate as a product of incomplete CoQ10 biosynthesis or from the diet.

1. Lekli I, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56 (13):5331-7.
2. Duncan, A.J., Bitner-Glindzicz, M., Meunier, B.,et al.A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: A potentially treatable form of mitochondrial disease.American Journal of Human Genetics84 (5),558-566 (2009).
3. Lapointe, J., Wang, Y., Bigras, E.,et al.The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/-mice.Journal of Cell Biology199 (2),215-224 (2012).

Small volumes of Coenzyme Q9, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5751943 is an inhibitor targeting Coenzyme Q9.