CAFESTOL Inhibitor

Name: CAFESTOL Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752079
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752079

CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CAFESTOL, Inhibitor

Full Product Name

CAFESTOL

Product Gene Name

CAFESTOL, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

316.43

Formula

C20H28O3

CAS

469-83-0

Smiles

[H][C@]12CC[C@@]34C[C@@H](CC[C@@]3([H])[C@]1(C)CCc1occc21)[C@@](O)(CO)C4

Receptor (IC50)

ERK, COX-2, NF-kappaB

Solubility

DMSO: 5mg/mL (15.8mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for CAFESTOL, inhibitor

Home; NF-kappab; NF-kappaB

Product References and Citations for CAFESTOL, inhibitor

1. 1. Shen T, Lee J, Lee E, et al. Cafestol, a Coffee-Specific Diterpene, Is a Novel Extracellular Signal-Regulated Kinase Inhibitor with AP-1-Targeted Inhibition of Prostaglandin E2 Production in Lipopolysaccharide-Activated Macrophages[J]. Biological & Pharmaceutical Bulletin, 2010, 33 (1):128-132.
2. Mellbye F B, Jeppesen P B, Shokouh P, et al. Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice[J]. Journal of Natural Products, 2017:acs.jnatprod.7b00395.

Other Notes

Small volumes of CAFESTOL, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAFESTOL purchase

MBS5752079 is an inhibitor targeting CAFESTOL.