Bevirimat Inhibitor

Name: Bevirimat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752131
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752131

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bevirimat, Inhibitor

Full Product Name

Bevirimat

Product Synonym Names

PA-457; MPC-4326; YK FH312

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

584.83

Formula

C36H56O6

CAS

174022-42-5

Smiles

[H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CC(C)(C)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C

Receptor (IC50)

HIV-1

Solubility

DMSO: 50mg/mL (85.49mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Bevirimat, inhibitor

Home; Microbiology & virology; HIV Protease

Product References and Citations for Bevirimat, inhibitor

1. Smith P F, Ogundele A, Forrest A, et al. Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O- (3',3'-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection[J]. Antimicrobial Agents & Chemotherapy, 2007, 51 (10):3574.
2. Purdy MD, Shi D, Chrustowicz J,et al.MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat[J].Proc Natl Acad Sci U S A. 2018 Dec 26;115 (52):13258-13263.
3. Stoddart C A, Pheroze J, Barbara S, et al. Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice[J]. PLoS ONE, 2007, 2 (11):e1251-.

Other Notes

Small volumes of Bevirimat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bevirimat purchase

MBS5752131 is an inhibitor targeting Bevirimat.