Topotecan Inhibitor

Name: Topotecan Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752133
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752133

Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Topotecan, Inhibitor

Full Product Name

Topotecan

Product Synonym Names

SKF 104864A; NSC 609669

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

421.45

Formula

C23H23N3O5

CAS

123948-87-8

Smiles

CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O

Receptor (IC50)

Eukaryotic topoisomerase I

Solubility

DMSO: 84mg/mL (199.31mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Topotecan, inhibitor

Home; DNA Damage/DNA Repair; Topoisomerase

Product References and Citations for Topotecan, inhibitor

1. Feng-Lei Z, Ping W, Yun-Hui L, et al. Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells[J]. PLoS ONE, 2013, 8 (11):e81815-.
2. Taich P, Moretton M A, Del Sole, María Jose, et al. Sustained-release hydrogels of topotecan for retinoblastoma[J]. Colloids and Surfaces B: Biointerfaces, 2016, 146:624-631.

Other Notes

Small volumes of Topotecan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Topotecan purchase

MBS5752133 is an inhibitor targeting Topotecan.