Trametinib DMSO solvate Inhibitor

Name: Trametinib DMSO solvate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752199
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752199

Trametinib DMSO solvate is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2 (IC50 :2nM) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Trametinib DMSO solvate, Inhibitor

Full Product Name

Trametinib DMSO solvate

Product Synonym Names

GSK-1120212 (DMSO solvate); Trametinib dimethyl sulfoxide; JTP-74057 (DMSO solvate)

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

693.53

Formula

C28H29FIN5O5S

CAS

1187431-43-1

Smiles

CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

Receptor (IC50)

MEK1/2: 2nM

Solubility

DMSO: 69mg/mL (99.49mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Trametinib DMSO solvate, inhibitor

Home; MAPK; MEK

Product References and Citations for Trametinib DMSO solvate, inhibitor

1. Abe H, Kikuchi S, Hayakawa K, et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)[J]. ACS MEDICINAL CHEMISTRY LETTERS, 2011, 2 (4):320-324.

Other Notes

Small volumes of Trametinib DMSO solvate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Trametinib DMSO solvate purchase

MBS5752199 is an inhibitor targeting Trametinib DMSO solvate.