CK-869 Inhibitor

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor (IC50 of 7uM),and is useful tools for the investigation of the Arp2/3 complex.

1. Yvonne B, Vasquez R J, Jonathan S, et al. Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly[J]. PLoS ONE, 2014, 9 (6):e100943-.
2. Yamagishi Y, Oya K, Matsuura A, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo[J]. Biochemical and Biophysical Research Communications, 2018, 496 (3):834-839.
3. Hetrick B, Han M, Helgeson L, et al. Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change[J]. Chemistry & Biology, 2013, 20 (5):701-712.

Small volumes of CK-869, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752201 is an inhibitor targeting CK-869.