ARN-3236 Inhibitor

Name: ARN-3236 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752258
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752258

ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARN-3236, Inhibitor

Full Product Name

ARN-3236

Product Gene Name

ARN-3236, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

336.41

Formula

C19H16N2O2S

CAS

1613710-01-2

Smiles

COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1

Receptor (IC50)

SIK2: <1nM
SIK1: 21.63nM
SIK3: 6.63nM

Solubility

DMSO: 130mg/mL (386.43mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for ARN-3236, inhibitor

Home; Others

Product References and Citations for ARN-3236, inhibitor

1. Zhou J, Alfraidi A, Zhang S, et al. A novel compound ARN-3236 inhibits Salt Inducible Kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel[J]. Clinical Cancer Research, 2016:1078-0432.CCR-16-1562.
2. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99 (5):711-21.
3. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts. Clin Cancer Res. 2017 Apr 15;23 (8):1945-1954.

Other Notes

Small volumes of ARN-3236, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARN-3236 purchase

MBS5752258 is an inhibitor targeting ARN-3236.