Leonurine Inhibitor

Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.

1. Jiang T, Ren K, Chen Q, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppargamma/Lxralpha Signaling Pathway-Dependent Manner[J]. Cellular Physiology and Biochemistry, 2017:1-1.
2. Jia M, Li C, Zheng Y, et al. Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation[J]. International Journal of Neuropsychopharmacology, 2017.
3. Zhang L, Li H X, Pan W S, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway[J]. Biomedicine & Pharmacotherapy, 2019, 110:571-581.
4. Hu ZC, et al. Inhibition of PI3K/Akt/NF-kappaB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.

Small volumes of Leonurine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752271 is an inhibitor targeting Leonurine.