KB-R7943 Inhibitor

Name: KB-R7943 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752278
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752278

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7+/-2.1uM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KB-R7943, Inhibitor

Full Product Name

KB-R7943

Product Gene Name

KB-R7943, inhibitor

Product Synonym Names

KB-R7943 mesylate

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

427.5

Formula

C17H21N3O6S2

CAS

182004-65-5

Smiles

CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1

Receptor (IC50)

Na+/Ca2+ exchanger: 5.7 +/- 2.1uM

Solubility

DMSO: 27mg/mL (63.16mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for KB-R7943, inhibitor

Home; Others

Product References and Citations for KB-R7943, inhibitor

1. Brustovetsky T, Brittain M K, Sheets P L, et al. KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I.[J]. British Journal of Pharmacology, 2015, 162 (1):255-270.
2. Barrientos G, Bose D D, Feng W, et al. The Na+/Ca2+ Exchange Inhibitor 2- (2- (4- (4-Nitrobenzyloxy)phenyl)ethyl)isothiourea Methanesulfonate (KB-R7943) Also Blocks Ryanodine Receptors Type 1 (RyR1) and Type 2 (RyR2) Channels[J]. Molecular Pharmacology, 2009, 76 (3):560-568.
3. Long Z, et al. The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. Oncotarget. 2016;7 (27):42059-70.

Other Notes

Small volumes of KB-R7943, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KB-R7943 purchase

MBS5752278 is an inhibitor targeting KB-R7943.