Nortadalafil Inhibitor

Name: Nortadalafil Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752279
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752279

Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nortadalafil, Inhibitor

Full Product Name

Nortadalafil

Product Synonym Names

Demethyl Tadalafil

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

375.38

Formula

C21H16N3O4

CAS

171596-36-4

Smiles

O=C1CNC(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1

Receptor (IC50)

PDE5

Solubility

DMSO: 50mg/mL (133.20mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Nortadalafil, inhibitor

Home; Metabolism; PDE

Product References and Citations for Nortadalafil, inhibitor

1. Takahiro R, Nakamura S, Kohno H, et al. Contribution of CYP3A Isoforms to Dealkylation of PDE5 Inhibitors: A Comparison between Sildenafil N-Demethylation and Tadalafil Demethylenation[J]. Biological & Pharmaceutical Bulletin, 2015, 38 (1):58-65.
2. Daugan A. The Discovery of Tadalafil : A Novel and Highly Selective PDE5 Inhibitor. 2:2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Analogues[J]. J. Med. Chem. 2003, 46.

Other Notes

Small volumes of Nortadalafil, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nortadalafil purchase

MBS5752279 is an inhibitor targeting Nortadalafil.