CVT-12012 Inhibitor

Name: CVT-12012 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752284
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752284

CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1nM in HepG2 cells). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CVT-12012, Inhibitor

Full Product Name

CVT-12012

Product Gene Name

CVT-12012, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

434.41

Formula

C21H21F3N4O3

CAS

1018675-35-8

Smiles

Cc1nc2ccc(NCc3cccc(c3)C(F)(F)F)cc2n(CCNC(=O)CO)c1=O

Receptor (IC50)

rat microsomal: 38nM
human HEPG2: 6.1nM

Solubility

DMSO: 125mg/mL (287.75mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for CVT-12012, inhibitor

Home; Others

Product References and Citations for CVT-12012, inhibitor

1. Koltun D O, Vasilevich N I, Parkhill E Q, et al. Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (11):3050-3053.
2. Atkinson KA, Beretta EE, Brown JA,et al.N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors[J].Bioorg Med Chem Lett. 2011 Mar 15;21 (6):1621-5.

Other Notes

Small volumes of CVT-12012, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CVT-12012 purchase

MBS5752284 is an inhibitor targeting CVT-12012.