EMD638683 Inhibitor

Name: EMD638683 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752285
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752285

EMD638683,a novel SGK inhibitor with antihypertensive potency (with an IC50 of 3uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EMD638683, Inhibitor

Full Product Name

EMD638683

Product Gene Name

EMD638683, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

364.34

Formula

C18H18F2N2O4

CAS

1181770-72-8

Smiles

CCc1c(C)c(O)ccc1C(=O)NNC(=O)C(O)c1cc(F)cc(F)c1

Receptor (IC50)

SGK1: 3uM

Solubility

DMSO: 50mg/mL (137.23mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for EMD638683, inhibitor

Home; Metabolism; SGK

Product References and Citations for EMD638683, inhibitor

1. Towhid S T, Liu G L, Ackermann T F, et al. Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683[J]. Cellular Physiology and Biochemistry, 2013, 32 (4):838-848.
2. Ackermann TF, Boini KM, Beier N,et al.EMD638683, a novel SGK inhibitor with antihypertensive potency[J].Cell Physiol Biochem. 2011;28 (1):137-46.
3. Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9):3737-49.

Other Notes

Small volumes of EMD638683, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EMD638683 purchase

MBS5752285 is an inhibitor targeting EMD638683.