IITZ-01 Inhibitor

Name: IITZ-01 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752286
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752286

IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity (IC50 of 2.62uM for PI3Kgamma.) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IITZ-01, Inhibitor

Full Product Name

IITZ-01

Product Gene Name

IITZ-01, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

482.51

Formula

C26H23FN8O

CAS

1807988-47-1

Smiles

Fc1ccc(Nc2nc(Nc3ccc(cc3)-c3nc4ccccc4[nH]3)nc(n2)N2CCOCC2)cc1

Receptor (IC50)

PI3Kgamma: 2.62uM

Solubility

DMSO: 150mg/mL (310.87mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for IITZ-01, inhibitor

Home; Autophagy; Autophagy

Product References and Citations for IITZ-01, inhibitor

1. Guntuku L, Gangasani JK, Thummuri D,et al.IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo[J]. Oncogene. 2019 Jan;38 (4):581-595.

Other Notes

Small volumes of IITZ-01, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IITZ-01 purchase

MBS5752286 is an inhibitor targeting IITZ-01.