Y15 Inhibitor

Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.

1. O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics[J].Oncotarget. 2014 Sep 15;5 (17):7945-59.
2. Zheng D, Golubovskaya V, Kurenova E, et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts[J]. Molecular Carcinogenesis, 2010, 49 (2):0-0.
3. Hochwald S N, Nyberg C, Zheng M, et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer[J]. Cell Cycle, 2009, 8 (15):2435-2443.

Small volumes of Y15, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752337 is an inhibitor targeting Y15.