AMG-47a Inhibitor

Name: AMG-47a Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752341
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752341

AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMG-47a, Inhibitor

Full Product Name

AMG-47a

Product Gene Name

AMG-47a, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

535.56

Formula

C29H28F3N5O2

CAS

882663-88-9

Smiles

Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1

Receptor (IC50)

Lck

Solubility

DMSO: 34mg/mL (63.48mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for AMG-47a, inhibitor

Home; Angiogenesis; Src

Product References and Citations for AMG-47a, inhibitor

1. Carver J, Dexheimer T S, Hsu D, et al. A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein[J]. Plos One, 2014, 9 (8):e103836.

Other Notes

Small volumes of AMG-47a, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMG-47a purchase

MBS5752341 is an inhibitor targeting AMG-47a.