Basmisanil Inhibitor

Name: Basmisanil Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752376
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752376

Basmisanil is a negative allosteric modulator/inverse agonist of GABAAalpha5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Basmisanil, Inhibitor

Full Product Name

Basmisanil

Product Synonym Names

RG1662; RO5186582

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

445.46

Formula

C21H20FN3O5S

CAS

1159600-41-5

Smiles

Cc1onc(c1COc1ccc(cn1)C(=O)N1CCS(=O)(=O)CC1)-c1ccc(F)cc1

Receptor (IC50)

GABAAalpha5

Solubility

DMSO: 32mg/mL (71.84mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Basmisanil, inhibitor

Home; Membrane transporter/Ion Channel

Product References and Citations for Basmisanil, inhibitor

1. Szepes, Anikó, Pabst-Ravot A, Storch K, et al. Stability and compatibility of Basmisanil granules co-administered with soft food[J]. International Journal of Pharmaceutics, 2018.
2. Myers J F, Comley R A, Gunn R N. Quantification of [ 11 C]Ro15-4513 GABA A alpha5 specific binding and regional selectivity in humans[J]. Journal of Cerebral Blood Flow & Metabolism, 2016, 37 (6):0271678X16661339.

Other Notes

Small volumes of Basmisanil, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Basmisanil purchase

MBS5752376 is an inhibitor targeting Basmisanil.