GNE-493 Inhibitor

Name: GNE-493 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752377
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752377

GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4nM, 12nM, 16nM, 16nM and 32nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma and mTOR,respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNE-493, Inhibitor

Full Product Name

GNE-493

Product Gene Name

GNE-493, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

372.44

Formula

C17H20N6O2S

CAS

1033735-94-2

Smiles

CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1

Receptor (IC50)

PI3Kalpha: 3.4nM
PI3Kbeta: 12nM
PI3Kdelta: 16nM
PI3Kgamma: 16nM
mTOR: 32nM

Solubility

DMSO: 45mg/mL (120.82mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GNE-493, inhibitor

Home; PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for GNE-493, inhibitor

1. Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer[J]. Journal of Medicinal Chemistry, 2010, 53 (3):1086-1097.

Other Notes

Small volumes of GNE-493, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-493 purchase

MBS5752377 is an inhibitor targeting GNE-493.