CPI-444 Inhibitor

Name: CPI-444 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752389
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752389

CPI-444 is an antagonist of the adenosine A2A receptor.It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CPI-444, Inhibitor

Full Product Name

CPI-444

Product Gene Name

CPI-444, inhibitor

Product Synonym Names

V81444; ciforadenant

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

407.43

Formula

C20H21N7O3

CAS

1202402-40-1

Smiles

Cc1ccc(o1)-c1nc(N)nc2n(Cc3cccc(CO[C@H]4CCOC4)n3)nnc12

Receptor (IC50)

A2A

Solubility

DMSO: 67.5mg/mL (165.67mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for CPI-444, inhibitor

Home; GPCR/G Protein; Adenosine Receptor

Product References and Citations for CPI-444, inhibitor

2. Willingham Stephen B, Ho Po Y, Hotson Andrew,?. A2AR Antagonism with CPI-444 Induces Anti-Tumor Responses and Augments Efficacy to Anti-PD- (L)1 and Anti-CTLA-4 in Preclinical Models.[J]. Cancer Immunology Research:canimm.0056.2018-.
3. Stephen Willingham, et al. Abstract PR04: CPI-444: A potent and selective inhibitor of A2AR induces antitumor responses alone and in combination with anti-PD-L1 in preclinical and clinical studies.Cancer Immunoly Research. September 25-28, 2016.

Other Notes

Small volumes of CPI-444, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPI-444 purchase

MBS5752389 is an inhibitor targeting CPI-444.