E-4031 Inhibitor

Name: E-4031 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752402
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752402

E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29nM) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

E-4031, Inhibitor

Full Product Name

E-4031

Product Gene Name

E-4031, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

474.44

Formula

C21H29Cl2N3O3S

CAS

113559-13-0

Smiles

Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)n1

Receptor (IC50)

hERG Potassium Channel: 29nM

Solubility

H2O: 50mg/mL (105.39mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for E-4031, inhibitor

Home; Angiogenesis; EGFR

Product References and Citations for E-4031, inhibitor

1. David Z, Julia B, Gerlind F, et al. Pronounced Effects of HERG-Blockers E-4031 and Erythromycin on APD, Spatial APD Dispersion and Triangulation in Transgenic Long-QT Type 1 Rabbits[J]. PLoS ONE, 2014, 9 (9):e107210-.
2. Nalos L, Varkevisser R, Jonsson M K B, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes[J]. British Journal of Pharmacology, 2011, 165 (2):467-478.

Other Notes

Small volumes of E-4031, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E-4031 purchase

MBS5752402 is an inhibitor targeting E-4031.