TPPU Inhibitor

TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8nM, respectively)

1. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys[J]. British Journal of Pharmacology, 2012, 165.
2. Yao ES, Tang Y, Liu XH,et al.TPPU protects tau from H2O2-induced hyperphosphorylation in HEK293/tau cells by regulating PI3K/AKT/GSK-3beta pathway[J].J Huazhong Univ Sci Technolog Med Sci. 2016 Dec;36 (6):785-790.
3. Ostermann AI, et al. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1- (1-propanoylpiperidin-4-yl)-3-[4- (trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 2015 Sep;121 (Pt A):131-7.
4. Ren Q, et al. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America (2016), 113 (13), E1944-E1952.

Small volumes of TPPU, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752403 is an inhibitor targeting TPPU.