Nelociguat Inhibitor

Name: Nelociguat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752405
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752405

Nelociguat (BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nelociguat, Inhibitor

Full Product Name

Nelociguat

Product Synonym Names

BAY60-4552

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

408.39

Formula

C19H17FN8O2

CAS

625115-52-8

Smiles

COC(=O)Nc1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12

Receptor (IC50)

Guanylate Cyclase

Solubility

DMSO: 105mg/mL (257.11mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Nelociguat, inhibitor

Home; Others

Product References and Citations for Nelociguat, inhibitor

1. Oudot A, Behr-Roussel D, Poirier S, et al. Combination of BAY 60-4552 and Vardenafil Exerts Proerectile Facilitator Effects in Rats With Cavernous Nerve Injury: A Proof of Concept Study for the Treatment of Phosphodiesterase Type 5 Inhibitor Failure[J]. European Urology, 2011, 60 (5):1020-1026.
2. Costell M H, Nicolas A, Bernard R E, et al. Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress[J]. Frontiers in Pharmacology, 2012, 3.

Other Notes

Small volumes of Nelociguat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nelociguat purchase

MBS5752405 is an inhibitor targeting Nelociguat.