PNU74654 Inhibitor – PNU 74654

Name: PNU74654 Inhibitor; PNU 74654; MyBioSource
Brand: MyBioSource
SKU: MBS5752408
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752408

PNU 74654 binds to beta-catenin (Kd = 450nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PNU 74654 (PNU74654), Inhibitor

Full Product Name

PNU 74654

Product Gene Name

PNU74654, inhibitor

Product Synonym Names

PNU-74654

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

320.34

Formula

C19H16N2O3

CAS

113906-27-7

Smiles

Cc1ccc(\C=N\NC(=O)c2ccccc2Oc2ccccc2)o1

Receptor (IC50)

Wnt/beta-catenin

Solubility

DMSO: 30mg/mL (93.65mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for PNU74654, inhibitor

Home; Cytoskeletal Signaling; Wnt/beta-catenin

Product References and Citations for PNU74654, inhibitor

1. Leal, Letícia F, Bueno A C, Gomes, Débora C, et al. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis[J]. Oncotarget, 2015, 6 (40).
2. Durand J, Lampron A, Mazzuco T L, et al. Characterization of Differential Gene Expression in Adrenocortical Tumors Harboring beta-Catenin (CTNNB1) Mutations[J]. The Journal of Clinical Endocrinology and Metabolism, 2011, 96 (7):E1206-11.

Other Notes

Small volumes of PNU74654, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PNU74654 purchase

MBS5752408 is an inhibitor targeting PNU74654. Also known as PNU 74654.