NM107 Inhibitor

NM107 is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase,nM 107 in the wild-type replicon cells with the EC50 of 1.85uM

1. Goris N, De Palma A, Toussaint, JeanFrançois, et al. 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus[J]. Antiviral Research, 2007, 73 (3):161-168.
2. Rochapereira J, Dycke J V, Neyts J. Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants[J]. Antimicrobial Agents & Chemotherapy, 2015, 60 (3):AAC.02198-15.
3. Guedj J, Dahari H, Rong L, et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life[J]. Proceedings of the National Academy of Sciences, 2013, 110 (10):3991-3996.

Small volumes of NM107, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752418 is an inhibitor targeting NM107.