SMS2-IN-2 Inhibitor

Name: SMS2-IN-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752431
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752431

SMS2-IN-2 is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56uM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SMS2-IN-2, Inhibitor

Full Product Name

SMS2-IN-2

Product Gene Name

SMS2-IN-2, inhibitor

Product Synonym Names

SMS2 inhibitors

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

369.78

Formula

C19H13ClFN3O2

CAS

2241838-28-6

Smiles

Fc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1

Receptor (IC50)

SMS2

Solubility

DMSO: 250mg/mL (676.08mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for SMS2-IN-2, inhibitor

Home; Others

Product References and Citations for SMS2-IN-2, inhibitor

1. Mo M, Yang J, Jiang XC,et al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61 (18):8241-8254.

Other Notes

Small volumes of SMS2-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMS2-IN-2 purchase

MBS5752431 is an inhibitor targeting SMS2-IN-2.