Tenofovir alafenamide fumarate Inhibitor

Name: Tenofovir alafenamide fumarate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752438
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752438

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tenofovir alafenamide fumarate, Inhibitor

Full Product Name

Tenofovir alafenamide fumarate

Product Synonym Names

Tenofovir alafenamide hemifumarate; GS-7340(hemifumarate)

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

534.5

Formula

C21H29N6O5P.1/2C4H4O4

CAS

1392275-56-7

Smiles

OC(=O)\C=C\C(O)=O.CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc1ccccc1.CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc1ccccc1

Receptor (IC50)

HIV-1

Solubility

DMSO: 50mg/mL (93.55mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Tenofovir alafenamide fumarate, inhibitor

Home; Microbiology & virology; HIV Protease

Product References and Citations for Tenofovir alafenamide fumarate, inhibitor

1. Birkus G, Bam RA, Willkom M,et al.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors[J].Antimicrob Agents Chemother. 2015 Oct 26;60 (1):316-22.
2. Callebaut C, Stepan G, Tian Y, et al. In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to Tenofovir Disoproxil Fumarate[J]. Antimicrobial Agents and Chemotherapy, 2015:AAC.01152-15.

Other Notes

Small volumes of Tenofovir alafenamide fumarate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tenofovir alafenamide fumarate purchase

MBS5752438 is an inhibitor targeting Tenofovir alafenamide fumarate.