GDC-0575 Inhibitor

Name: GDC-0575 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752448
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752448

GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor (IC50 of 1.2nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GDC-0575, Inhibitor

Full Product Name

GDC-0575

Product Gene Name

GDC-0575, inhibitor

Product Synonym Names

ARRY-575; RG7741

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

378.27

Formula

C16H20BrN5O

CAS

1196541-47-5

Smiles

N[C@@H]1CCCN(C1)c1c(Br)cnc2[nH]cc(NC(=O)C3CC3)c12

Receptor (IC50)

Chk1: 1.2nM

Solubility

DMSO: 50mg/mL (132.18mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GDC-0575, inhibitor

Home; Cell Cycle/Checkpoint; Chk

Product References and Citations for GDC-0575, inhibitor

1. Oo Z Y, Stevenson A J, Proctor M A, et al. Endogenous replication stress marks melanomas sensitive to CHK1 inhibitors in vivo[J]. Clinical Cancer Research, 2018:clincanres.2701.2017.
2. Tullio A D, Rouault-Pierre K, Abarrategi A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia[J]. Nature Communications, 2017, 8 (1):1679.
3. Laroche-Clary A, et al. CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. Ann Oncol. 2018 Apr 1;29 (4):1023-1029.
4. Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8 (1):1679.

Other Notes

Small volumes of GDC-0575, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0575 purchase

MBS5752448 is an inhibitor targeting GDC-0575.