Vorasidenib Inhibitor

Name: Vorasidenib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752454
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752454

Vorasidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7nM for IDH1R132H and IDH2R140Q, respectively) More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vorasidenib, Inhibitor

Full Product Name

Vorasidenib

Product Synonym Names

AG-881; PVM/MA

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

414.74

Formula

C14H13ClF6N6

CAS

1644545-52-7

Smiles

C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F

Receptor (IC50)

IDH1R132H: 31.9nM
IDH2R140Q: 31.7nM

Solubility

DMSO: 125mg/mL (301.39mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Vorasidenib, inhibitor

Home; Others

Product References and Citations for Vorasidenib, inhibitor

1. Zakkula A, Dittakavi S, ManiyarmM,et al.Validated HPLC method for simultaneous quantification of mutant IDH1/2 inhibitors (enasidenib, ivosidenib and vorasidenib) in mouse plasma: Application to a pharmacokinetic study[J].Biomed Chromatogr. 2019 Nov;33 (11):e4658.
2. Tianfang M, Fangxia Z, Stefan P, et al. Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): an Update and Perspective[J]. Journal of Medicinal Chemistry, 2018:acs.jmedchem.8b00159-.
3. Fujii T, et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21 (117):373-80.

Other Notes

Small volumes of Vorasidenib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vorasidenib purchase

MBS5752454 is an inhibitor targeting Vorasidenib.