Paquinimod Inhibitor

MBS5752457 is an inhibitor targeting Paquinimod. Paquinimod is a S100A9 inhibitor preventing S100A9 binding to TLR-4.

1. Schelbergen R F, Geven E J, Van d B M H J, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis[J]. Annals of the Rheumatic Diseases, 2015:annrheumdis-2014-206517.
2. StenstrM M, Nyhlén, Helén Carlsson, T Rngren M, et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis[J]. Journal of Dermatological Science, 2016:S0923181116300615.
2. StenstrM M, Nyhlén, Helén Carlsson, TRngren M, et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis[J]. Journal of Dermatological Science, 2016:S0923181116300615.
3. Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13 (5):e0196598.

Small volumes of Paquinimod, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.