Theliatinib Inhibitor

Name: Theliatinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752467
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752467

Theliatinib, a potent and highly selective EGFR inhibitor, with anti-tumor activity. Ki of 0.05nM for wild type EGFR, and IC50s of 3 and 22nM for EGFR and EGFR T790M/L858R mutant, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Theliatinib, Inhibitor

Full Product Name

Theliatinib

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

442.5

Formula

C25H26N6O2

CAS

1353644-70-8

Smiles

[H][C@]12CCN(C)[C@@]1([H])CN(C2)C(=O)Nc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OC

Receptor (IC50)

EGFR

Solubility

DMSO: 47mg/mL (106.21mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Theliatinib, inhibitor

Home; Angiogenesis; EGFR

Product References and Citations for Theliatinib, inhibitor

1. Ren Y, Zheng J, Fan S, et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification.[J]. Oncotarget, 2017, 8 (31):50832-50844.
2. Ren Y, et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. Oncotarget. 2017 Apr 19;8 (31):50832-50844.

Other Notes

Small volumes of Theliatinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Theliatinib purchase

MBS5752467 is an inhibitor targeting Theliatinib.